Objective To summarize research progress of non-coding RNAs (ncRNAs) in acute pancreatitis (AP), so as to provide new ideas for pathogenesis, diagnosis, and therapy of AP.Method The literatures on studies of ncRNAs in AP in recent years were read and reviewed.Results The incidence of AP was currently increasing, but its etiology was diverse, and its pathogenesis was still fully unclear. In recent years, a large number of studies had confirmed that the ncRNA played an important role in the occurrence of many cellulars and diseases processes. Through continuous exploration for potential mechanisms of AP based on ncRNA (including long non coding RNA and microRNA) function, it was found that the specificity and sensitivity of ncRNAs in the diagnosis of AP were better than of the traditional biomarkers. Meanwhile, ncRNAs were involved in the regulation of inflammatory response through a variety of ways.Conclusions Changes of ncRNAs expression in physiological functions of AP is involved in a variety of ways, it might provide new ideas for understanding pathogenesis of AP and help to find new therapeutic targets. A variety of ncRNAs closely related to AP are expected to become biomarkers and molecular targets for early diagnosis and treatment of AP, so as to achieve early diagnosis and targeted treatment of AP.