• Department of Thyroid Surgery, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, P. R. China;
DAI Wenjie, Email: davidhmu@163.com
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Objective In order to improve the clinical diagnosis and treatment of differentiated thyroid cancer, the research status and progress of blood markers of differentiated thyroid cancer in recent years were reviewed.Method The literatures about blood markers and liquid biopsy of differentiated thyroid cancer at home and abroad in recent years were searched and summarize.Results Thyroglobulin and thyroglobulin antibody were the most commonly used markers of differentiated thyroid cancer. The application value of blood markers such as microRNA and long non-coding RNA in the diagnosis, treatment and follow-up of differentiated thyroid cancer had also been found.Conclusion Because of the advantages of high specificity, high sensitivity and non-invasive, blood markers are useful indicators to help improve the diagnosis of thyroid cancer patients, monitor the disease progression and recurrence in the future.