• Department of Hepatobiliary and Pancreatic Surgery, Kunming First People’s Hospital, Kunming 650100, P. R. China;
HU Zongqiang, Email: 2509484088@qq.com
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Objective To summarize the research status of the relationship between hepatitis B virus X protein (HBx), hepatitis B virus (HBV) genotypes and hepatocellular carcinoma at home and abroad, and to prospect its clinical significance.Method The literatures about HBx, HBV genotypes and hepatocellular carcinoma were reviewed.Results There was a close relationship between HBx and the occurrence, development, migration and metastasis of hepatocellular carcinoma. There was a certain association between HBV genotypes and HCC, but the specific mechanism had not been clarified.Conclusions HBx and HBV genotypes play an important role in the occurrence and development of hepatocellular carcinoma. With the further study of molecular mechanism, it will promote the diagnosis and treatment of hepatitis B, liver cirrhosis and liver cancer, and provide more individualized intervention for clinical workers.