Objective To investigate the relationship between the expression of IL-8 in triple negative breast cancer (TNBC) and clinicopathological features and survival prognosis.Methods The expression of IL-8 protein in 80 cases of TNBC was detected by immunohistochemical staining, and the relationship between the expression of IL-8 protein and clinicopathological features and prognosis of TNBC patients was analyzed by Kaplan-Meier survival curve and Cox multivariate regression.Results In 80 TNBC patients, the high expression of IL-8 protein accounted for 22.5% (18/80). Univariate analysis showed that the expression level of IL-8 protein in TNBC tumor tissue was correlated with T stage, clinical stage, Ki-67 expression, WHO grade and lymph node metastasis (P<0.05). However, it was not related to age, menopausal status, pathological type of tumor and whether they had received neoadjuvant chemotherapy (P>0.05). The results of Kaplan-Meier survival analysis showed that the 2-year cumulative disease-free survival rate (DFS) of high expression group of IL-8 protein was lower than that of low expression group of IL-8 protein (P<0.05). Multivariate Cox proportional regression analysis showed that the expression of IL-8 protein was an independent factor affecting the survival and prognosis of TNBC patients [HR=1.180, 95%CI (1.001, 1.391), P=0.049]. The prognosis of TNBC patients with high expression of IL-8 protein was poor.Conclusion The expression level of IL-8 is an independent risk factor affecting the survival and prognosis of patients with TNBC.