• Department of General Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China;
SUN Xuejun, Email: sunxy@mail.xjtu.edu.cn
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Objective To investigate the expressions of hypoxia-inducible factor-1α (HIF-1α) and caudal homeobox gene 2 (CDX2) in colorectal adenocarcinoma, and the relationships between them and the clinicopathologic factor of colorectal adenocarcinoma. Methods The expressions of HIF-1α and CDX2 were detected by immunohistochemistry in 62 specimens of colorectal adenocarcinoma and 20 specimens of normal colorectal mucosa tissue. The correlation between the expressions of HIF-1α and CDX2 was analyzed by Spearman rank correlation analysis. Results The positive rates of HIF-1α expression in normal colorectal mucosa tissue and colorectal adenocarcinoma were 5.0% (1/20) and 62.9% (39/62), CDX2 were 95.0% (19/20) and 69.4% (43/62), the differences of positive rate between different tissues were significant (P lt;0.05). In colorectal adenocarcinoma, the expression of HIF-1α or CDX2 was related to tumor differentiation, lymph node metastasis, and Dukes staging (P lt;0.05). There was a negative correlation between HIF-1α and CDX2 expressions in colorectal adenocarcinoma (r=-0.293 2,P lt;0.05). Conclusions The up-regulation of HIF-1α and down-regulation of CDX2 may be involved in the genesis of colorectal adenocarcinoma, and there is a negative correlation between the two kinds of protein. HIF-1α may participate in modulation of CDX2 expression and lead to accelerate the progression of colorectal carcinoma.

Citation: ZHENG Jianbao,SUN Xuejun,WANG Wei,LI Shoushuai,REN Hailiang,LU Shaoying,SHI Jingsen.. Expressions of HIF-1α and CDX2 and Its Clinical Pathological Significance in Colorectal Adenocarcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(12): 1265-1269. doi: Copy