• Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, Liaoning Province, China;
LI Xiaoxia, Email: lxx555999@yahoo.com.cn
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Objective  To analyze the clinical pathological features of patients with hereditary nonpolyposis colorectal cancer (HNPCC) in northeast Chinese.
Methods  The clinical data of 101 probands (HNPCC group) from 1982 to 2011 in the Fourth Affiliated Hospital of China Medical University and Tumor hospital of Liaoning Province and 272 patients with sporadic colorectal cancer (sporadic CRC group) in the same period were collected. The clinicopathologic features were compared in two groups.
Results  In the HNPCC group, the age of onset was younger than 45 years old in 24 patients (23.8%), proximal colon in 31 (30.7%), multiple primary carcinomas in 26 (25.7%), extracolonic carcinoma in 13 (12.9%), mucinous adenocarcinoma in 32 (31.7%), phaseⅠandⅡin 68 (67.3%), high-middle differentiation in 70 (69.3%), and lymph node metastasis in 33 (32.7%), while in the sporadic CRC group were 12 (4.4%), 54 (19.9%), 15 (5.5%), 11 (4.0%), 30 (11.0%), 127 (46.7%), 152 (55.9%), and 140 (51.5%), respectively. There were significant differences between the HNPCC group and the sporadic CRC group (P<0.05). Meanwhile, extracolonic carcinomas in the HNPCC group were endometrial cancer in 3, bladder cancer in 3, breast cancer in 2, brain tumor in 2, ovarian cancer in 1, gastric cancer in 1, and lung cancer in 1.
Conclusions  Northeast China HNPCC patients with several particular clinicopathologic features such as early onset, frequent localization in proximal colon, proclivity of synchronous and metachronous tumors, excessive mucinous adenocarcinoma, less poorly differentiated tumors, lymph node metastasis, early stage of tumor, and so on. Therefore, clinicopathologic feature is still a preferred method of diagnosis of HNPCC patients or suspected HNPCC patients.

Citation: YAN Yifei,LI Xiaoxia,TANG Yuanxin,LI Xin,SUN Gongping,ZHAO Meng,MENG Jin,LIANG Gaofeng,.. Clinicopathologic Features Analysis of Patients with Hereditary Nonpolyposis Colorectal Cancer in Northeast Chinese. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(2): 138-142. doi: Copy

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