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find Keyword "发病" 188 results
  • 新型冠状病毒感染伴发癫痫及其发病机制与脑电图改变

    新型冠状病毒感染(Corona virus disease 2019,COVID-19)是一种由冠状病毒(SARS-CoV-2)导致的新型传染性疾病。关于COVID-19与癫痫之间的关系,有研究认为癫痫发作和COVID-19无明显关系;但也有不少学者认为,癫痫发作是COVID-19的继发症状,甚至是早期症状。COVID-19患者中癫痫发作发生率为0.08%~1.9%。COVID-19出现癫痫发作的直接发病机制是,SARS-COV-2能够直接进入并感染中枢神经系统,引起脑膜炎和脑炎,从而引起癫痫发作。间接发病机制包括:中枢神经系统炎症(细胞因子风暴)、血-脑屏障的破坏、凝血异常、脑卒中、线粒体功能异常、电解质紊乱。新发作和频发癫痫发作的患者可能导致预后更差,死亡率更高。COVID-19伴发癫痫患者中脑电图(Electroencephalogram,EEG)改变的主要表现为:基本节律不同程度的慢化、节律性慢活动、癫痫样放电(包括周期性放电和散在性棘波、尖波等)。癫痫患者EEG的异常部位主要分布在额叶,然而,异常EEG表现并无特异性。

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  • 芳香族抗癫痫药物所致严重皮肤不良反应的研究进展

    芳香族抗癫痫药物(AEDs)所致皮肤不良反应在临床治疗过程中较为常见,其中严重皮肤不良反应可对患者的生命造成致死性威胁。现主要对芳香族AEDs所致严重皮肤不良反应的临床表现、可能机制及治疗方法等方面的研究进行综述,从而进一步指导合理用药避免其不良反应的发生。

    Release date:2017-07-26 04:06 Export PDF Favorites Scan
  • Research progress on the relationship between breast cancer treatment and atrial fibrillation

    Atrial fibrillation (AF) and breast cancer are common diseases with high incidence, which can be promoted and maintained by a wide range of regulatory factors (changes of hormone secretion, chronic inflammation, dysfunctions in autonomic nervous system, coagulation system and endothelia). There may be a consistent pathophysiological link between the increased incidence of breast cancer and AF, which is currently seldomly reported. The development process of these two diseases are complex, and the occurrence of breast cancer may increase the incidence of AF. In this paper, we reviewed the relationship between breast cancer and AF based on the latest reports.

    Release date:2020-07-30 02:32 Export PDF Favorites Scan
  • Trends and projections of incidence and mortality of acute viral hepatitis in China from 1990 to 2021

    Objective To analyze the incidence and mortality of acute viral hepatitis in China, project its trends from 2022 to 2030, and provide valuable insights for the prevention and control of viral hepatitis. Methods The incidence and mortality rates of acute viral hepatitis in China from 1990 to 2021 were extracted from the Global Burden of Disease 2021 database. The change rates and the estimated annual percentage change (EAPC) for each indicator were calculated. Additionally, an autoregressive integrated moving average (ARIMA) model was used to project the incidence and mortality of acute viral hepatitis in China from 2022 to 2030. Results From 1990 to 2021, the incidence rates of acute hepatitis A (AHA), acute hepatitis B (AHB), acute hepatitis C (AHC), and acute hepatitis E (AHE) in China all showed a declining trend (EAPC=−1.980%, −2.664%, −2.078%, −1.686%; P<0.05), with a particularly marked decrease in mortality (EAPC=−11.662%, −7.411%, −12.541%, −7.504%; P<0.05). According to ARIMA model projections, the incidence rates of AHA and AHB were expected to continue declining from 2022 to 2030, while the incidence rates of AHC and AHE were expected to rise. In 2030, the projected incidence rates of AHA, AHB, AHC, and AHE were 890.425/100000, 824.158/100000, 59.202/100000, and 300.377/100000, respectively. The mortality rates of AHA, AHC, and AHE were projected to remain stable from 2022 to 2030, while the mortality rate of AHB was expected to decline. In 2030, the projected mortality rates of AHA, AHB, AHC, and AHE were 0.002/100000, 0/100000, 0.004/100000, and 0.011/100000, respectively. Conclusions From 1990 to 2021, the overall incidence and mortality of acute viral hepatitis in China showed a downward trend. However, the incidence rates of AHC and AHE may present an upward trend in the future, which suggests that the government and relevant health authorities should adjust their prevention and control strategies in a timely manner.

    Release date:2025-07-29 05:02 Export PDF Favorites Scan
  • Incidence trends of tuberculosis among Chinese students: a systematic review

    ObjectiveTo systematically review the trend of tuberculosis among Chinese students. MethodsPubMed, Web of Science, EMbase, CBM, WanFang Data and CNKI databases were electronically searched to collect cross-sectional studies on the incidence and trend of tuberculosis among students in China from inception to August 2021. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies; then, meta-analysis was performed by using Stata 15.0 software. ResultsA total of 97 cross-sectional studies were included. The results of meta-analysis showed that: the overall incidence of tuberculosis among students in China was 18.63 per 100 000 persons. The incidence in the northwest, south, northeast, north, east, central, and southwest 46.81, 11.22, 24.38, 12.77, 12.03, 18.95, and 39.26 per 100 000 persons, respectively. The incidence among university students, senior high school students, junior school students, and primary school students 38.17, 33.84, 8.85, and 1.68 per 100 000 persons, respectively. ConclusionCurrent evidence shows that the incidence of tuberculosis among students in China is high. Among them, the incidence rate of tuberculosis in the central and western regions, universities and high school students is relatively high.

    Release date:2022-02-12 11:14 Export PDF Favorites Scan
  • 视网膜动脉栓子的流行病学研究进展

    视网膜动脉栓子在成人发病率较低, 但视网膜动脉栓子的形成与颈动脉斑块及狭窄和多种心血管疾病相关。近年来的研究表明, 视网膜动脉栓子可能提示脑卒中发作的危险性及致死率增高, 是心血管因素之外的独立高危因素。因此, 提高对视网膜动脉栓子的流行病学认识, 及时进行全面的心脑血管检查评估, 有助于及早发现、确诊和治疗心脑血管疾病, 降低心脑血管疾病的致死率。

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  • A Screening Study on Premature Infants with Retinopathy of Prematurity

    【摘要】 目的 探讨早产儿视网膜病变(retinopathy of prematurity,ROP)的发生率及危险因素。 方法 收集2007年12月-2008年12月在四川省人民医院、成都市妇幼保健院、成都市妇产科医院住院的85例体重≤2 000 g或有严重疾病的早产儿,自出生后4~6周或矫正胎龄32周开始筛查,至周边视网膜血管化。 结果 85例早产儿中,有9例发生ROP,发病率10.58%。其中出生体重lt;1 500 g的早产儿ROP发病率为17.07%,孕周lt;30周的早产儿ROP发病率为40%。 结论 低体重、胎龄小、吸氧为早产儿发生ROP的重要危险因素;尽早进行眼底筛查是早期发现、诊断及治疗ROP的关键。【Abstract】 Objective To investigate the occurrence and risk factors of retinopathy of prematurity (ROP). Methods A total of 85 premature infants were enrolled from Sichuan provincial people′s hospital, Chengdu maternal and child health hospital, and Chengdu obstetric and gynecology hospital. The infants were born between December 2007 and December 2008, with a birth weight less than 2 000 g. The ocular funds examination was carried out four to six weeks after the birth or at the 32nd week of the corrected gestational age;the infants were followed up until the retina was entirely vascularized. Results ROP was found in 9 of the 85 premature infants, with a percentage of 10.58%. About 17.07% premature infants with a birth weight less than 1500 g and 40% infants with a gestational age shorter than 30 weeks had ROP. Conclusions A lower birth weight, a shorter gestational age and oxygen usage are the risk factors of ROP. It′s important to examine the ocular fundus in premature infants as early as possible so as to identify, diagnose and treat ROP at an early stage.

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • KCNT1 基因变异相关癫痫及其治疗的研究进展

    KCNT1基因编码含有1 235个氨基酸的钠离子门控钾离子通道的α亚基,对调节神经元的膜兴奋性发挥着重要作用,其致病性变异可通过影响钾通道的功能导致癫痫。KCNT1基因变异相关癫痫患者表型具有显著临床异质性,可出现从轻度表型到严重表型的系列癫痫表型谱,为难治性癫痫大多数,严重表型患者可伴有运动、智能发育落后或倒退,预后极差。早期识别KCNT1基因变异相关癫痫,及时进行KCNT1基因检测,有利于KCNT1基因变异相关癫痫患者的精准治疗及预后评估。在此,本文就KCNT1基因变异相关癫痫的发病机制、临床特点及其治疗进行综述。

    Release date:2022-06-27 04:41 Export PDF Favorites Scan
  • 特发性全面性癫痫易感基因的研究

    随着生物信息学的飞速发展, 特发性全面性癫痫(Genetic generalized epilepsy, GGE)发病被证实与遗传因素密切相关, 越来越多的易感基因被发现, 同时其发病机制亦陆续被深入研究。大部分的突变基因为编码离子通道蛋白的基因, 但离子通道基因突变仅能解释GGE的少数家系或散发病例, 故对GGE的易感基因与发病机制进行阐明, 有利于GGE的后续遗传学研究。

    Release date:2017-01-22 09:09 Export PDF Favorites Scan
  • 急性百草枯中毒致急性肺损伤发病机制的研究进展

    百草枯中毒所致急性肺损伤是目前临床上百草枯中毒致死的主要因素,近年来对于其损伤机制的研究不断深入,但其具体机制尚不完全明确。现对近年来百草枯中毒肺损伤在炎症反应、氧化损伤、基因异常表达等方面的机制研究进行综述,以期为临床医生对百草枯中毒致肺损伤的治疗提供依据。

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