A controversy still exists in the management of nerve injection injury. The results of different timing of operation and methods in treating this type of nerve injury were analysed in limb s function, neuroelectrophysiology and histology. The results showed that the recovery of the injuried nerve in the group of operation, was considerably better than that in the group without operation. In the group of operation early incision of the epineurium with saline irrigation! was superior to late neurolysis. It was suggested that the early incision with saline irrigation could be used as an emergency management for this type of nerve injury.
In 50 animals, 100 nerve injections were carried out by using four drugs and the physiological saline was used as control. The pathological alterations in the nerve were evident as early as 1 hour after injection with splitting of the myelin larnellae in local areas. At 24 hours, there were areas of complete delamination and fragmentetion of the myelin sheath. Some axons had completely disintegreted. A remarkable reduction in the amplitude of nerve-muscle action potentials was indicative of early ncurophysiological changes in this type of nerve injury and the detection of this was conducive to its early diagnosis..