Objective The aim of this study is to review the association between long non-coding RNA (lncRNA) and papillary thyroid carcinoma (PTC). Method The relevant literatures about lncRNA associated with PTC were retrospectively analyzed and summarized. Results The expression levels of noncoding RNA associated with MAP kinase pathway and growth arrest (NAMA), PTC susceptibility candidate 3 (PTCSC3), BRAF activated non-coding RNA (BANCR), maternally expressed gene 3 (MEG3), NONHSAT037832, and GAS8-AS1 in PTC tissues were significantly lower than those in non-thyroid carcinoma tissues. The expression levels of ENST00000537266, ENST00000426615, XLOC051122, XLOC006074, HOX transcript antisense RNA (HOTAIR), antisense noncoding RNA in the INK4 locus (ANRIL), and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PTC tissues were upregulated in PTC tissues, comparing with the non-thyroid carcinoma tissues. These lncRNAs were possibly involved in cell proliferation, migration, and apoptosis of PTC. Conclusion LncRNAs may provide new insights into the molecular mechanism and gene-targeted therapy of PTC and become new molecular marker for the diagnosis of PTC.
Objective To investigate the changes of interleukin-17 ( IL-17) and the effects of propofol in rats with acute lung injury ( ALI) . Methods ALI model was established by hydrochloric acid ( HCl) inhalation in a dose of 2 mL/kg. 35 adultmale SD rats were randomly divided into seven groups, ie.a control group, a HCl group, and five propofol groups ( T24b , T12b , T0 , T1a , T3a groups, respectively) . The T0 ,T24b and T12b groups were pretreated with intraperitoneal propofol injection 0, 24 and 12 hours respectively before HCl inhalation. The T1a and T3a groups were managed by intraperitoneal propofol injection 1 and 3 hours respectively after HCl inhalation. Immunohistochemistry was used to determine the expression of IL-17 in lung tissue. ELISA was adopted to detect the levels of IL-17 and IL-8 in lung tissue homogenate as well as in bronchoalveolar lavage fluid ( BALF) , meanwhile arterial partial pressure of oxygen ( PaO2 ) and myeloperoxidase ( MPO) were measured. Results Those rats in the HCl group appeared respiratory distress, cyanosis, pulmonary edema, and inflammatory cells infiltration in lung tissues after HCl inhalation.The IL-17 levels in lung tissue homogenate as well as in BALF were higher in the HCl group than those in the control group( all P lt; 0. 01) . IL-17 was mainly expressed in alveolar epithelial cells and mononuclear cells in the ALI rats and its expression level was higher than that in the control group. IL-17 concentration in lung tissue homogenate was both correlated with IL-8 concentration in lung tissue homogenate ( r=0. 98, P =0.003) and with the activity of MPO in lung tissue( r=0. 981, P =0. 003) in the HCl group. Mainwhile, a same significant correlation was found between IL-8 level in lung tissue homogenate and the MPO activity in the HCl group( r =0. 961, P =0. 009) . Propofol attenuated lung injury induced by HCl inhalation, especially in T24b group. The concentrations of IL-17 in lung tissue homogenate and in BALF were lower in T24b group when compared with the HCl group( P = 0. 011, P =0. 003, respectively) . Conclusions The expression of IL-17 increases in ALI rats. Pretreatment with propofol by 24 hours has obvious inhibiting effects on inflammatory reaction. Inhibiting IL-17 expression may be one of the mechanisms through which propofol inhibits the inflammatory reaction of ALI.
ObjectiveTo summarize the relationship between exosome and thyroid diseases.MethodThe literatures reports on exosomes and the physiology, pathology and diseases of thyroid were collected and reviewed.ResultsExosomes were secreted by cells and could be found in various body fluids, which could mediate the normal physiological development of the thyroid gland and play an important role in the progression of Graves’ disease. Exosomes could be used as diagnostic and differential diagnostic biomarkers for thyroid cancer and affect the growth, invasion, and metastasis of thyroid cancer. As a drug carrier for anti-thyroid cancer, exosome had a good targeting ability.ConclusionExosomes play an important role in the development of various diseases of the thyroid gland, which have good application prospects in biomarkers for early diagnosis and prognostic evaluation, as well as targeted drug carriers for thyroid cancer.
ObjectiveTo compare the citations of Chinese literature in the 2015 and 2025 editions of the American Thyroid Association (ATA) guidelines, thereby evaluating the progress in the field of differentiated thyroid cancer (DTC) in China. MethodsChinese literature cited in the 2015 and 2025 ATA guidelines was collected and cataloged. Comparisons were made between the two editions regarding the number of citations, source journals, affiliated institutions, regional distribution, research types, and research foci. Results① Changes in the quantity and regional distribution of Chinese citations: The proportion of Chinese literature cited in the 2025 ATA guidelines increased nearly threefold compared to the 2015 edition (8.8% vs. 3.3%, P<0.001). The number of source journals increased nearly fourfold, the number of contributing cities more than doubled, and the number of involved hospital institutions quadrupled. Compared to the 2015 edition, where cited institutions were primarily located in Taiwan (11 publications), Hong Kong (11 publications), and coastal cities in Mainland China (12 publications), the 2025 edition showed a broader distribution encompassing medical centers in the Beijing-Tianjin-Hebei region, Yangtze River Delta, Pearl River Delta, Chengdu, Changchun, among others. West China Hospital of Sichuan University led the nation with the most citations (20 publications). The proportion of citations from Mainland Chinese institutions increased significantly compared to those from Taiwan and Hong Kong (accounting for 84.5%).② Changes in research types of cited literature: Clinical research constituted the majority (>95%) of cited Chinese literature in both editions. However, three basic research studies appeared in the 2025 edition. Single-center studies predominated in both guidelines.③ Changes in research foci of cited literature: The number of research foci covered increased nearly twofold in the 2025 edition (20 foci) compared to the 2015 edition (11 foci). Radioactive Iodine (RAI-131) therapy was the most frequently cited focus in both editions. Among research foci with ≥5 citations, traditional areas like tumor staging & prognosis and surgical methods & extent remained prominent, while the focus on recurrent laryngeal nerve protection rose in rank. Some traditional foci declined in ranking. Notable newly prominent or significantly changed foci included ablation therapy (12 publications, ranked 2nd), comprehensive treatment (11 publications), lymph node metastasis (10 publications), parathyroid protection (7 publications), thyroid cancer & pregnancy risks (5 publications), and active surveillance (5 publications). ConclusionCompared to the 2015 ATA guidelines, the 2025 edition cited a higher proportion of Chinese literature, demonstrated a wider geographical distribution of publications (expanding from Taiwan, Hong Kong, and coastal developed areas to major regional centers across China), and covered broader and more in-depth research foci. This indicates significant growth in China's DTC field in recent years, with a gradual shift from traditional concerns like cure and recurrence rates towards improving long-term quality of life and developing personalized, precise comprehensive management models. China is playing an increasingly important role in shaping global DTC standards. However, high-quality prospective, multicenter, randomized clinical trials remain an area for future enhancement.