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find Keyword "障碍" 445 results
  • Changes of Pulmonary Diffusing Capacity and Pulmonary Capillary Blood Volume in Stable COPD Patients with Mixed Ventilation Dysfunction

    Objective To investigate the changes of pulmonary diffusing capacity and pulmonary capillary blood volume in stable COPD patients with mixed ventilation dysfunction, and explore the possible pathophysiological factors. Methods 159 stable COPD patients with mixed ventilation dysfunction were recruited in the study and 36 normal subjects were recruited as control. The Belgium medisoft box5500 was used to determine the pulmonary ventilation function, lung capacity, and pulmonary diffusing capacity. The measured parameters included forced vital capacity ( FVC) , forced expiratory volume in one second ( FEV1 ) ,maximal voluntary ventilation ( MVV) , vital capacity ( VC) , total lung capacity( TLC) , residual volume ( RV) , minute volume of alveolar ventilation ( VA ) , lung diffusing capacity for carbon monoxide ( DLCO) , pulmonary membrane diffusing capacity for carbon monoxide ( DMCO) , and pulmonary capillary blood volume ( Vc) . The above parameters were compared between the COPD patients and the normal subjects. The relationship was analyzed between DLCO% pred, DMCO% pred, Vc% pred and all the ventilation parameters. Results In stable COPD patients with mixed ventilation dysfunction, all parameters of pulmonary ventilation function, lung capacity, and pulmonary diffusing capacity were significantly different from the normal subjects ( Plt;0. 05 or Plt;0.01) . FVC, VC, VA, and DMCO of the COPD patients were about 66% of the calculated value or more. The average TLC%pred was a little higher than the normal. FEV1 , MVV, DLCO and Vc were abnormally lower which were between 36% ~44% . The average RV%pred was 188% of the predicted value. Obvious correlation could be detected between DLCO% pred, DMCO% pred, Vc%pred and FEV1%pred, FEV1/FVC, TLC% pred, RV%pred, RV/TLC and VA% pred etc.Conclusions In COPD patients with mixed ventilation dysfunction, the pulmonary blood capillary is damaged seriously which lead to a significant decrease of the capacity of pulmonary blood capillary, as well as seriously air distribution disturbance and ventilation/bloodstream mismatch. The Vc decline may develope before the impairment of pulmonary diffusing capacity which may contribute to the damaged of DLCO and DMCO.

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  • Regulation of CⅡTA to Major Histocompatibility Complex Class Ⅱ Gene in Multiple Organ Dysfunction Syndrome

    目的 探讨主要组织相容性复合体(MHC)Ⅱ类基因的反式转录因子(CⅡTA)在多器官功能障碍综合征(MODS)中对MHCⅡ类基因的调控机理。方法 18只雄性家猪随机分为实验组(n=9)和对照组(n=9)。实验组给予失血性休克、再灌注损伤、内毒素血症等复合干扰因素,建立二次打击猪MODS模型; 对照组仅进行麻醉和动静脉插管。7 d后处死存活动物。切取实验组造模成功动物和对照组动物的脾脏组织,用Trizol法提取总RNA。设计CⅡTA和猪MHCⅡ类基因(SLA-DQA)引物序列,逆转录构建cDNA,行实时荧光定量PCR检测。UVP计算机图像分析系统绘出标准曲线并得出2组CⅡTA mRNA和SLA-DQA mRNA的拷贝数。以Pearson法分析MODS动物CⅡTA mRNA和SLA-DQA mRNA表达的相关性。结果 实验组动物死亡7例,有8例发生MODS。对照组动物CⅡTA mRNA的拷贝数为(3.516±1.237)×103,实验组MODS动物为(0.367±0.088)×103,差异有统计学意义(P=0.000); 对照组SLA-DQA mRNA拷贝数为(5.330±3.053)×103,实验组为(1.376±1.006)×103,差异亦有统计学意义(P=0.002)。MODS动物中CⅡTA mRNA和SLA-DQA mRNA的表达呈正相关(Pearson值为0.499,P=0.017)。结论 MODS模型复制满意。MHCⅡ类基因在MODS中表达下降与CⅡTA的调控有关。

    Release date:2016-09-08 10:50 Export PDF Favorites Scan
  • PROGRESS IN DIAGNOSIS AND TREATMENT OF CHRONIC DISORDERS OF ACHILLES TENDON

    Objective To review the progress in the diagnosis and treatment of chronic disorders of achilles tendon. Methods Recent l iterature concerning the diagnosis and treatment of chronic disorders of achilles tendon was revi ewed. Results Ultrasonography and MRI were commonly used for diagnoses, and MRI could provide extensive informationfor the choice of therapy protocol. Nonsurgical therapy was the mainstay of treatment for most patients with overuse syndromes, surgical techniques for patients due to no effect in the conservative treatment and with chronic rupture, the cl inical treatment project should be determined based on the cl inical evaluation. Conclusion The surgical indication of chronic disorders of achilles tendon remains controversial, the long-term results of each treatment method are unknown, the randomized prospective studies are still required.

    Release date:2016-08-31 05:48 Export PDF Favorites Scan
  • Effects of digastric muscle low frequency modulated medium frequency electroacupuncture therapy and voice training for dysphagia in patients with aortic arch surgery: A randomized controlled trial

    Objective To investigate the combined effects of digastric muscle low frequency modulated medium frequency electro-acupuncture therapy and voice training for dysphagia in patients who underwent aortic arch surgery. Methods Forty-two consecutive patients with dysphagia after aortic arch surgery between October 2014 and November 2017 were divided into two groups including an observation group and a control group. There were 21 patients in each group. There were 17 males and 4 females at age of 51.0±6.5 years in the observation group, while 18 males and 3 females at age of 49.8±7.3 years in the control group. The patients in the observation group underwent electroacupuncture therapy and voice training (20 min per day for each therapy, 2 weeks), while the patients in the control group only received safe swallowing education and rehabilitation guidance (2 weeks). The test results, such as fibrolaryngoscope and functional oral intake scale (FOIS) score, and the data of computer phonatory detection, before and after the intervention were compared. Results The fibrolaryngoscope of vocal cords significantly decreased and the FOIS score significantly increased after digastric muscle low frequency modulated medium frequency electro-acupuncture therapy and voice training in the observation group(6.30 vs. 4.60, P<0.05). Bucking was obviously reduced. The indicators of hoarse degree, such as median pitch, fundamental frequency, jitter (0.60%±0.96%vs. 1.99%±1.86%, P=0.033), shimmer (2.47%±4.26% vs. 5.89%±3.66%, P=0.043), maximum phonation time (15.31±9.10 s vs. 3.72±8.83 s, P=0.006), maximum and loud phonation time (9.30±5.73 s vs. 2.32±2.99 s, P=0.039), mean noise-to-harmonics ratio (23.99±10.17 vs .9.98±9.37, P=0.006) and mean harmonics-to-noise ratio (0.03±0.02 vs. 0.17±0.23, P=0.019) improved after the treatment in both groups. But the improvement in the observation group was significantly better than that in the control group. Conclusion The combination of digastric muscle low frequency modulated medium frequency electro-acupuncture therapy and voice training on dysphagia in patients who underwent aortic arch surgery can significantly improve the swallowing function of patients. Meanwhile, it also helps the recovery of phonic function and improves the ability of feeding and communication in these patients.

    Release date:2018-06-01 07:11 Export PDF Favorites Scan
  • 86例脑外伤合并多脏器功能障碍临床分析

    目的:探讨脑外伤合并多脏器功能障碍的发病机制与综合治疗方法。方法:回顾性分析2000年3月~2009年6月我院NICU中收治的脑外伤合并多脏器功能障碍患者86例的临床资料。 结果:394例脑外伤患者救治过程中出现多脏器功能障碍综合征86例(发生率为21.83%),其中死亡56例(病死率65.12%)。 结论:及时有效地缓解颅内高压、恢复脑干功能是治疗的首要问题;而肺部继发症的合理治疗是控制多脏器功能障碍综合征的重要环节;综合救治策略仍然是降低病死率的关键手段。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • Three-dimensional virtual dolphin treatment system for children with autism spectrum disorder

    In order to address the problem of traditional dolphin adjuvant therapy such as high cost and its limitation in time and place, this paper introduces a three-dimensional virtual dolphin adjuvant therapy system based on virtual reality technology. By adopting Oculus wearable three-dimensional display, the system combined natural human-computer interaction based on Leap Motion with high-precision gesture recognition and cognitive training, and achieved immersive three-dimensional interactive game for child rehabilitation training purposes. The experimental data showed that the system can effectively improve the cognitive and social abilities of those children with autism spectrum disorder, providing a useful exploration for the rehabilitation of those children.

    Release date:2017-08-21 04:00 Export PDF Favorites Scan
  • Analysis of risk factors for cognitive dysfunction in patients with epilepsy

    ObjectiveTo analyze the risk factors of cognitive dysfunction in patients with epilepsy, and provide evidence for clinical prevention and treatment.MethodsDuring the period from January 1, 2018 to January 31, 2019, 101 patients with epilepsy who were admitted to the epilepsy specialist clinic of the General Hospital of Ningxia Medical University were included in this study. The cognitive function of the patients was evaluated by the Mini-mental State Examination (MMSE) scale and patients were divided into cognitive impairment group and normal cognitive function group according to the MMSE. Single factor and logistic regression analysis were used to find the differences of influencing factors between the two groups.Results① There were 27 cases of cognitive dysfunction in 101 patients with epilepsy, the incidence of cognitive impairment was 26.7%; ② Univariate analysis showed that the course of disease, frequency of seizures, seizure forms, anti-epileptic drugs (AEDs) and abnormal rate of electroencephalogram (EEG) existed significant differences between the two groups (P<0.05). ③ Logistic regression showed that course of disease, frequency of seizures and AEDs multidrug therapy were independent risk factors for cognitive dysfunction in patients with epilepsy (P<0.05).ConclusionCourse of disease, frequency of seizures and AEDs multidrug therapy are independent risk factors for cognitive dysfunction in patients with epilepsy.

    Release date:2019-05-21 08:51 Export PDF Favorites Scan
  • 卒中后吞咽障碍者早期康复护理

    【摘要】 目的 观察早期康复护理对卒中后吞咽障碍患者的临床疗效影响。方法 2006年1月—2008年12月,65例脑卒中合并吞咽障碍患者接受了早期康复专项护理(包括刺激咽部,练习屏气和发音,唇、舌、颊部力量训练,吸吮训练和喉抬高训练等),67例同期住院仅接受常规康复护理同病患者为对照组。两组患者干预前后接受日本康复医学会编制的“吞咽困难评估量表”评分和日常生活能力评估。结果 两组患者治疗前吞咽障碍评分接近,治疗后均明显高于治疗前,同时专项护理组治疗后评分也明显高于对照组(Plt;0.05)。专项护理组吞咽障碍症状基本痊愈16例(24.62%),好转21例(32.31%),有效18例(27.69%),无效10例(15.38%),总有效率为84.62%,明显优于对照组(68.65%)(Plt;0.01)。结论 早期康复护理可明显改善卒中后吞咽障碍患者的临床疗效。

    Release date:2016-09-08 09:37 Export PDF Favorites Scan
  • 视网膜变性和功能不良性疾病动物模型的研究现状

    随着医学分子生物学技术的发展,对各种视网膜变性和功能不良性疾病发病机制的研究及疾病治疗的探索有了进一步的深入,试验型活体基因治疗将是未来最有希望挽救视网膜感光细胞的治疗手段,因而建立相应的疾病动物模型,有着比以往更为重要的作用,从遗传学、转基因技术及有道德动物模型三方面对视网膜变性疾病的动物模型研究作进一步综述。 (中华眼底病杂志,2004,20:54-57)

    Release date:2016-09-02 05:58 Export PDF Favorites Scan
  • Long-Term Effects of Partial Axillary Dissection in Modified Radical Mastectomy of Breast Cancer

    Objective To study the effects of partial axillary lymph node dissection (PALD) on prognosis and upper limb function in patients with breast cancer. Methods Ninety-eight breast cancer patients with stage Ⅰ and Ⅱ were randomly divided into two groups and different surgical procedures following modified mastectomy were performed: partial axillary lymph node (level Ⅰ and Ⅱ) dissection (PALD) group (n=48) and total axillary lymph node (levelⅠ, Ⅱ and Ⅲ) dissection (TALD) group (n=50). The longterm positive relapse rate and upper limb function between 2 groups were compared. Results During the follow-up of 5 to 10 years (average 4.5 years), there were 2 cases (4.2%) of local recurrence on chest wall and one case (2.1%) of recurrence in axillary lymph node and one case (2.1%) of recurrence in supraclavicular lymph node in PALD group, and 2 cases (4.0%) of local recurrence on chest wall and no axillary lymph node recurrence and one case (2.0%) of recurrence in supraclavicular lymph node happened in TALD group. There was no statistical difference between PALD group and TALD group (Pgt;0.05). The incidence of upper limb edema and dysfunction was 4.2% (2/48) in PALD group and 16.0%(8/50) in TALD group (P<0.01). There was no significant statistical difference of 5year and 10year survival rate between PALD group and TALD group (89.6% vs. 88.0%, 79.2% vs. 78.0%,Pgt;0.05). Conclusion PALD may reduce upper limb dysfunction after operation in patients with stage Ⅰ and Ⅱ breast cancer, and does not increase prognostic risk.

    Release date:2016-09-08 11:05 Export PDF Favorites Scan
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